The final quest of the Patch 10.1 Campaign is available after the weekly reset on NA realms! You can start the quest by talking to Ebyssian near the entrance to Aberrus.
It is, however, worth noting that starting the final chapter DOES require completion of the quest Aberrus, the Shadowed Crucible: Sarkareth, which requires a Scalecommander Sarkareth kill in Aberrus. Players who have not completed this quest will not be able to start the final chapter of the 10.1 Campaign.
